|
KMID : 0607519970050010089
|
|
Korean Journal of Psychosomatic Medicine
1997 Volume.5 No. 1 p.89 ~ p.96
|
|
|
Cognitive Impairment in the Patients with Mildly Active Systemic Lupus Erythematosus
|
|
Kim Jin-Hee
Lee Chul
Lee Chang-Uk
Paik In-Ho
|
|
|
Abstract
|
|
|
Object: This study was designed to determine whether cognitive impairment was evident in patients with SLE. Also, it aimed to examine the association of cognitive impairment with other clinical variables. The subjects consisted of 20 patients with mildly active SLE and 20 healthy controls.
Methods: A total of 20 SLE patients and 20 normal controls completed a computerized neuropsychological test battery using Vienna Test System. These included Cognitrone test, Continuous attention test, Corsi block tapping test, Standard progressive matrices. Also, neuro-behavioral cognitive status examination was done. The symptom severity of depression was measured with Beck Depression Inventory, Hamilton Depression Rating Scale, and current medications were documented. Disease activity was rated using the SLE diasease activity index (SLEDAI).
Results: SLE patients had poorer performance than normal controls on the tests of Cognitrone, attention, nonverbal IQ and memory, independent of age, education, disease activity, steroid use and depression status.
Conclusion: Cognitive dysfunction was not uncommon in ambulatory SLE patients as measured by standardized neuropsychological tests. It seemed to occur independently of various clinical variables. These findings would suggest that cognitive dysfunction in SLE may be explained by reflecting subclinical central nervous system(CNS) involvement, rather than coexisting psychological distress due to chronic illness or side effect of medication.
|
|
|
KEYWORD
|
|
|
Systemic lupus erythematosus, Cognitive dysfunction Neuropsychological test, Disease activity, Depression, Steroid
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|